Document Type : Original Article
Authors
1
Medical Biochemistry& Molecular Biology, Faculty of Medicine, Menoufia University, Egypt
2
Dermatology & Andrology, Faculty of Medicine, Menoufia University, Egypt
3
Diagnostic Radiology, Faculty of Medicine, Menoufia University, Egypt
4
Cardiology Departments, Faculty of Medicine, Menoufia University, Egypt.
Abstract
Chemerin, leptin and psoriasin are pro-inflammatory and immune-modulatory proteins associated with psoriasis and displayed higher circulating levels. Their relation to atherosclerosis in psoriatic patients has been investigated in numerous studies with wide-ranging results. Therefore, the present study aimed to assess plasma levels of chemerin, leptin and psoriasin and evaluate their relationship with carotid intima-media thickness (CIMT) and epicardial fat thickness (EFT) as potential predictors for subclinical atherosclerosis in psoriasis patients. The study included fifty psoriatic patients and forty age and gender matched healthy controls. Clinical severity of psoriasis was evaluated by Psoriasis Area and Severity Index (PASI). Fasting blood glucose and lipid profile were estimated. Plasma levels of high sensitivity-CRP (hs-CRP), chemerin, leptin and psoriasin were measured by ELISA. CIMT and EFT were assessed by Ultrasonography and Echocardiography, respectively. Plasma levels of hs-CRP, chemerin, leptin and psoriasin as well as CIMT and EFT were significantly elevated in psoriasis patients compared to controls. CIMT and EFT were significantly positively correlated with PASI, plasma hs-CRP, chemerin, leptin and psoriasin. Moreover, significant positive correlation was demonstrated between PASI and plasma hs-CRP, chemerin, leptin and psoriasin. Multiple linear regression analyses showed that chemerin, leptin and psoriasin were
independently correlated with CIMT and EFT and exhibited high
significance for predicting their values. It can be concluded that
chemerin, leptin and psoriasin might represent an important link
between psoriasis and atherosclerosis. Measurements of plasma
chemerin, leptin and psoriasin along with CIMT and EFT seem to be
valuable potential markers of subclinical atherosclerosis in patients
with psoriasis.
Keywords
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