INTEGRIN BETA 4 mRNA EXPRESSION LEVELS IN BRONCHIAL ASTHMA PATIENTS

Document Type : Original Article

Authors

1 Medical Biochemistry Faculty of Medicine, Menoufia University, Egypt

2 Chest Department DEPARTMENTS FACULTY OF MEDICINE, MENOUFIA UNIVERSITY, EGYPT

3 MEDICAL BIOCHEMISTRY AND INTERNAL MEDICINE DEPARTMENTS FACULTY OF MEDICINE, MENOUFIA UNIVERSITY, EGYP

Abstract

Integrin beta 4 (ITG4) is one of the integrin families that is engaged
in the maintenance of the integrity of airway epithelial cells. The aim
of this work was to evaluate the relationship between ITG4 mRNA
expression level and asthma susceptibility; and to analyze the
relevance of atopic asthma with the alteration of ITG4mRNA
expression level.Seventy five asthmatic patients and thirty age and
gender matched healthy controls were enrolled in this study. Serum
total IgE was measured by ELISA and mRNA expression of ITG4
was assessed by reverse transcriptase PCR (RT-PCR) using real time
PCR.. ITG4 mRNA expression was significantly down regulated
with increased serum total IgE in patients with asthma compared to
controls. Moreover, ITG4 expression was significantly reduced with
increased total IgE in atopic asthmatics compared to non-atopic
asthmatics.From this study, it could be concluded thatdown-regulation
of ITG4 expression is associated with asthma susceptibility mainly in
atopic cases irrespective of the degree of severity.

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