NRF2 AND P73 POLYMORPHISMS IN EGYPTIAN WOMEN WITH BREAST CANCER

Document Type : Original Article

Authors

1 BIOCHEMISTRY DEPARTMENT, FACULTY OF PHARMACY (GIRLS), AL AZHAR UNIVERSITY

2 CLINICAL PATHOLOGY DEPARTMENT, NATIONAL CANCER INSTITUTE, CAIRO UNIVERSITY

Abstract

The aim of the study was to assess the role of Nrf2 promoter and P73
G4C14 to A4T14 polymorphisms in breast cancer and the potential
relation to the onset of the disease. Eighty six female patients with
breast tumor were included in this study. Nrf2 (rs6721961) and p73
(G4A) genetic polymorphisms in promoter and exon2 region
respectively were investigated using PCR-CTPP assay. The genotype
frequencies of the three genotypes of Nrf2 promoter SNP (CC, CA,
AA) showed no significant difference between benign and malignant
groups. Genotype frequencies for P73 G4A SNP (GG, GA) showed no
significant difference between benign and malignant groups, no
patient have the AA genotype. Regarding the onset of disease, the
three Nrf2 genotypes in pre - and post-menopausal patients, showed
that the distribution differ significantly in the 2 patients groups and
that the AA genotype is significantly higher in the pre-menopausal
patients compared to post-menopausal patients. Nrf2 (rs6721961) AA
genotype might be related to early breast cancer onset. P73 G4A
polymorphism shows no relation to both disease risk and disease
onset. Therefore Nrf2 (rs6721961) promoter genotyping might be
related to the risk of pre-menopausal breast cancer.

Keywords

The Egyptian Journal of Biochemistry and Molecular Biology
Volume 33, 1-2
December 2015
Pages 82-95

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